Auditoría de Referencias

FERMENTACIÓN COLÓNICA, FIBRA PREBIÓTICA Y MICROBIOTA

  1. Birkeland E, Gharagozlian S, Birkeland KI, Valeur J, Måge I, Rud I, Aas AM. Prebiotic effect of inulin-type fructans on faecal microbiota and short-chain fatty acids in type 2 diabetes: a randomised controlled trial. Eur J Nutr. 2020;59(7):3325–3338. doi:10.1007/s00394-020-02282-5

  2. Liu F, Li P, Chen M, et al. Effect of Fructooligosaccharides Supplementation on the Gut Microbiota in Human: A Systematic Review and Meta-Analysis. Nutrients. 2022;14(16):3298. doi:10.3390/nu14163298

  3. So D, Whelan K, Rossi M, et al. Dietary fiber intervention on gut microbiota composition in healthy adults: a systematic review and meta-analysis. Am J Clin Nutr. 2018;107(6):965–983. doi:10.1093/ajcn/nqy041

  4. Canfora EE, et al. Fiber mixture-specific effect on distal colonic fermentation and metabolic health in lean but not in prediabetic men. Gut Microbes. 2022;14(1):2009297. doi:10.1080/19490976.2021.2009297

  5. García-Peris P, et al. Effect of a mixture of inulin and fructo-oligosaccharide on Lactobacillus and Bifidobacterium intestinal microbiota of patients receiving radiotherapy: a randomised, double-blind, placebo-controlled trial. Nutr Hosp. 2012;27(6):1908–1915.

  6. Rivière A, Selak M, Lantin D, Leroy F, De Vuyst L. Bifidobacteria and Butyrate-Producing Colon Bacteria: Importance and Strategies for Their Stimulation in the Human Gut. Front Microbiol. 2016;7:979. doi:10.3389/fmicb.2016.00979

  7. Meta-análisis: Effect of fructooligosaccharides supplementation on constipation in adults: a systematic review and meta-analysis of randomized controlled trials. Foods. 2024;13(24):3993.

  8. McDonald D, Hyde E, Debelius JW, et al. American Gut: an Open Platform for Citizen Science Microbiome Research. mSystems. 2018;3(3):e00031-18. doi:10.1128/mSystems.00031-18

  9. David LA, Maurice CF, Carmody RN, et al. Diet rapidly and reproducibly alters the human gut microbiome. Nature. 2014;505(7484):559–563. doi:10.1038/nature12820

ÁCIDOS GRASOS DE CADENA CORTA (AGCC)

  1. Salvi PS, Cowles RA. Butyrate and the Intestinal Epithelium: Modulation of Proliferation and Inflammation in Homeostasis and Disease. Cells. 2021;10(7):1775. doi:10.3390/cells10071775

  2. Silva YP, Bernardi A, Frozza RL. The Role of Short-Chain Fatty Acids From Gut Microbiota in Gut-Brain Communication. Front Endocrinol. 2020;11:25. doi:10.3389/fendo.2020.00025

  3. Dalile B, Van Oudenhove L, Vervliet B, Verbeke K. The role of short-chain fatty acids in microbiota–gut–brain communication. Nat Rev Gastroenterol Hepatol. 2019;16(8):461–478. doi:10.1038/s41575-019-0157-3

  4. Perler BK, Friedman ES, Wu GD. The Role of the Gut Microbiota in the Relationship Between Diet and Human Health. Annu Rev Physiol. 2023;85:449–468. doi:10.1146/annurev-physiol-031522-092054

EJE INTESTINO-CEREBRO

  1. Cryan JF, O'Riordan KJ, Cowan CSM, et al. The Microbiota-Gut-Brain Axis. Physiol Rev. 2019;99(4):1877–2013. doi:10.1152/physrev.00018.2018

  2. Simpson CA, Diaz-Arteche C, Eliby D, et al. The gut microbiota in anxiety and depression — A systematic review. Clin Psychol Rev. 2021;83:101943. doi:10.1016/j.cpr.2020.101943

EJE MÚSCULO-MICROBIOTA

  1. Scheiman J, Luber JM, Chavkin TA, et al. Meta-omics analysis of elite athletes identifies a performance-enhancing microbe that functions via lactate metabolism. Nat Med. 2019;25(7):1104–1109. doi:10.1038/s41591-019-0485-4

BARRERA INTESTINAL

  1. Di Tommaso N, Gasbarrini A, Ponziani FR. Intestinal Barrier in Human Health and Disease. Int J Environ Res Public Health. 2021;18(23):12836. doi:10.3390/ijerph182312836

  2. Abbasi F, Haghighat Lari MM, Khosravi GR, Mansouri E, Payandeh N, Milajerdi A. A systematic review and meta-analysis of clinical trials on the effects of glutamine supplementation on gut permeability in adults. Amino Acids. 2024;56(1):60. doi:10.1007/s00726-024-03420-7

INMUNIDAD Y MICROBIOTA

  1. Wiertsema SP, van Bergenhenegouwen J, Garssen J, Knippels LMJ. The Interplay between the Gut Microbiome and the Immune System in the Context of Infectious Diseases throughout Life and the Role of Nutrition in Optimizing Treatment Strategies. Nutrients. 2021;13(3):886. doi:10.3390/nu13030886

  2. Wastyk HC, Fragiadakis GK, Perelman D, et al. Gut-microbiota-targeted diets modulate human immune status. Cell. 2021;184(16):4137–4153.e14. doi:10.1016/j.cell.2021.06.019

BETA-ALANINA Y RENDIMIENTO

  1. Saunders B, et al. β-alanine supplementation to improve exercise capacity and performance: a systematic review and meta-analysis. Br J Sports Med. 2017;51(8):658–669. doi:10.1136/bjsports-2016-096396

POLIFENOLES Y MICROBIOTA

  1. González-Gómez Á, et al. Effect of Polyphenol-Rich Interventions on Gut Microbiota Composition: A Systematic Review and Meta-Analysis. Nutrients. 2025;17(15):2468.

  2. Ortiz T, et al. An Updated Review of the Health Benefits of Maqui Berry Extract. Nutrients. 2020;12(7):2106. doi:10.3390/nu12072106

CRONONUTRICIÓN Y RITMO CIRCADIANO BACTERIANO

  1. Zeb F, Osaili T, Obaid RS, et al. Gut Microbiota and Time-Restricted Feeding/Eating: A Targeted Biomarker and Approach in Precision Nutrition. Nutrients. 2023;15(2):259. doi:10.3390/nu15020259

  2. Jakubowicz D, et al. Interaction Between Early Meals (Big-Breakfast Diet), Clock, and Gut Microbiota. Int J Mol Sci. 2024;25(22):12355.

SUEÑO Y PREBIÓTICOS

  1. Tanihiro R, Sakano K, Oba S, et al. Effects of Prebiotic Yeast Mannan on Gut Health and Sleep Quality in Healthy Adults: A Randomized, Double-Blind, Placebo-Controlled Study. Nutrients. 2023;16(1):141. doi:10.3390/nu16010141

MICRONUTRIENTES Y COFACTORES

  1. Michels AJ, et al. Multivitamin/Multimineral Supplementation Prevents or Reverses Decline in Vitamin Biomarkers and Cellular Energy Metabolism: A Randomized, Double-Blind, Placebo-Controlled Study. Nutrients. 2023;15(12):2691.

EPIDEMIOLOGÍA NUTRICIONAL CHILE / LATINOAMÉRICA

  1. Fuentealba F, et al. Dietary Fibre Intake in Chile: 13 Years after the Last National Report. Nutrients. 2023;15(17):3671. doi:10.3390/nu15173671

  2. Castillo-Lancellotti C, et al. Folato y vitamina B12 en adultos mayores chilenos: Resultados ENS 2009-2010. Rev Med Chile. 2013.

  3. López de Romaña D, et al. Prevalence of Micronutrient Deficiencies in Latin America and the Caribbean. 2015.

  4. Encuesta Nacional de Salud 2016-2017. Ministerio de Salud, Gobierno de Chile. (Solo 15% cumple 5 porciones diarias de frutas y verduras.)

NOTA SOBRE NIVEL DE EVIDENCIA

Pulse Medical prioriza la evidencia de mayor calidad metodológica:

Meta-análisis y revisiones sistemáticas de RCTs: Refs 2, 3, 7, 18, 21 RCTs doble ciego con placebo: Refs 1, 4, 5, 26, 27 Estudios prospectivos en humanos: Refs 8, 9, 20 Reviews de alto impacto: Refs 6, 10, 11, 12, 13, 14, 15, 17, 19, 22, 23, 24, 25 Estudio observacional + experimental (Nature Medicine): Ref 16 — Scheiman et al. identificó el mecanismo Veillonella/lactato en atletas de élite con validación experimental en modelos animales. No es un RCT en humanos pero es un hallazgo seminal publicado en revista de máximo impacto. Epidemiología poblacional: Refs 28, 29, 30, 31

Pulse Medical · Nutrición de precisión basada en ciencia del microbioma humano. Cada ingrediente respaldado por evidencia. Cada dosis coherente con la literatura. Tu microbiota se entrena.